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HETRONIFLY 100MG

HETRONIFLY 100MG

19500.0 INR/Box

Product Details:

  • Origin of Medicine India
  • Brand Name INTAS
  • Ingredients Ingredients List Active Ingredient:Serplulimab: \(10 \text{ mg/mL}\) (Recombinant humanized IgG4 monoclonal antibody produced in Chinese hamster ovary, or CHO, cells) Inactive Ingredients (Excipients):Sodium chloride: Provides tonicity.Sodium citrate: Acts as a buffering agent to maintain pH.Citric acid monohydrate: Works alongside sodium citrate to maintain the product's pH (typically between 5.2 and 5.8).Mannitol: A sugar used as a bulking agent and stabilizer.Polysorbate 80: A surfactant used to prevent the monoclonal antibody from sticking to surfaces and aggregating.Water for Injections: The sterile solvent used to dissolve all ingredients
  • Physical Form Liquid
  • Dosage 300
  • Suitable For Adults, Aged Person
  • Quantity 1 Boxes
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HETRONIFLY 100MG Price And Quantity

  • 10 Box
  • 19500.0 INR/Box

HETRONIFLY 100MG Product Specifications

  • 2 TO 8
  • INTAS
  • 1 Boxes
  • India
  • Liquid
  • Ingredients List Active Ingredient:Serplulimab: \(10 \text{ mg/mL}\) (Recombinant humanized IgG4 monoclonal antibody produced in Chinese hamster ovary, or CHO, cells) Inactive Ingredients (Excipients):Sodium chloride: Provides tonicity.Sodium citrate: Acts as a buffering agent to maintain pH.Citric acid monohydrate: Works alongside sodium citrate to maintain the product's pH (typically between 5.2 and 5.8).Mannitol: A sugar used as a bulking agent and stabilizer.Polysorbate 80: A surfactant used to prevent the monoclonal antibody from sticking to surfaces and aggregating.Water for Injections: The sterile solvent used to dissolve all ingredients
  • 300
  • Adults, Aged Person

Product Description

1. General Characteristics
  • Brand/Generic: Serplulimab (INN), often marketed as Hetronifly or Zerpidio.
  • Dosage Form: Sterile concentrate for solution for infusion (intravenous drip).
  • Drug Class: Immune checkpoint inhibitor (recombinant humanized anti-PD-1 monoclonal antibody).
  • Mechanism: It blocks the PD-1 receptor on T-cells, preventing cancer cells from deactivating the immune system and helping the body destroy tumor cells. 
2. Physical Description
  • Appearance: Colourless to slightly yellow, and clear to slightly opalescent liquid.
  • Concentration: \(10\text{ mg/ml}\).
  • Packaging: Typically supplied in a single-use clear glass vial containing \(10\text{ ml}\) of concentrate (totaling \(100\text{ mg}\) of serplulimab). 
3. Composition & Excipients
  • Active Ingredient: Serplulimab (produced in Chinese hamster ovary cells via recombinant DNA technology).
  • Inactive Ingredients/Excipients: Sodium, polysorbate 80 (E 433), and Water for Injections.
  • pH Range: 5.2 to 5.8. 
4. Preparation & Administration
  • Dilution: Must be aseptically diluted in \(0.9\%\) Sodium Chloride injection before use.
  • Administration: Administered strictly via intravenous (IV) infusion (typically over 30 to 60 minutes).
  • Storage: Must be refrigerated continuously between \(2^{\circ}\text{C}\) and \(8^{\circ}\text{C}\) (\(36^{\circ}\text{F}\) to \(46^{\circ}\text{F}\)) and protected from light. 
5. Medical Indications
  • Used primarily as a first-line treatment for aggressive malignancies, such as extensive-stage small cell lung cancer (ES-SCLC).
  • Often prescribed in combination with chemotherapy (such as carboplatin and etoposide).
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