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Virolfi 450 mg is prescribed for two main purposes: 
  • Treatment of CMV Retinitis: It is used in adult patients with Acquired Immunodeficiency Syndrome (AIDS) to treat cytomegalovirus infection of the retina (retinitis), which is a serious eye infection that can lead to vision problems and blindness.
  • Prevention of CMV Infection: It helps prevent CMV disease in patients who have received a solid organ transplant (such as a kidney, heart, or pancreas) from a donor who was CMV-positive. 
How it Works
The medication works by being converted into ganciclovir within the body. Ganciclovir is the active form, which then inhibits the multiplication of the virus in human cells, effectively stopping the infection from producing new viruses and spreading. 
Important Considerations
  • Administration: Virolfi 450 mg tablets should be swallowed whole, not crushed or chewed, and taken with food to improve absorption.
  • Dosage: The dose and duration are determined by a doctor and depend on the patient's condition and response to treatment.
  • Side Effects: Common side effects include diarrhea, headache, nausea, vomiting, fever, fatigue, and low blood cell counts (anemia, low white blood cells, low platelets).
  • Precautions:
    • It may cause bone marrow suppression, requiring regular blood tests to monitor cell counts.
    • It is generally not recommended during pregnancy or breastfeeding due to potential harm to the baby.
    • Effective contraception is essential during and for a period after treatment for both men and women.
    • Patients with kidney problems may need a dosage adjustment.
    • Patients should drink plenty of water to stay hydrated and reduce the risk of kidney damage. 
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