Mechanism of Action: The medication works by blocking an enzyme called PARP (poly-ADP-ribose polymerase), which normally helps repair damaged DNA in cells. In cancer cells that rely heavily on this repair pathway (especially those with BRCA mutations), inhibiting PARP prevents DNA repair, leading to cell death and slowing tumor growth.
Uses: It is used in the treatment of various cancers, typically as a maintenance therapy after platinum-based chemotherapy has shown a response.
Ovarian cancer
Breast cancer
Pancreatic cancer
Prostate cancer
Administration: It is an oral tablet that should be swallowed whole with a glass of water, with or without food, as directed by a healthcare professional. It is usually taken at the same time every day to maintain a consistent level in the body.
Important Precautions:
Regular blood tests are required during treatment to monitor blood cell counts (red cells, white cells, and platelets) and liver function.
It is unsafe for use during pregnancy or breastfeeding, and effective contraception must be used during and for a period after treatment for both men and women.
Grapefruit or grapefruit juice should be avoided while taking this medicine, as it can increase the risk of side effects.
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