Tenofovir alafenamide (TAF) is an antiretroviral medication used in the treatment of HIV infection. It belongs to the class of drugs known as nucleotide reverse transcriptase inhibitors (NRTIs).
Tenofovir alafenamide is a prodrug of tenofovir, meaning it is metabolized in the body into its active form, tenofovir. Tenofovir works by inhibiting the action of reverse transcriptase, an enzyme that HIV needs to replicate. By interfering with HIV replication, tenofovir helps to reduce the viral load in the body and slow down the progression of HIV infection.
Tenofovir alafenamide is known for its improved safety profile compared to the older formulation of tenofovir, tenofovir disoproxil fumarate (TDF). It has been associated with lower risks of kidney toxicity and bone density loss.
The dosage of tenofovir alafenamide tablets can vary depending on the specific treatment regimen prescribed by a healthcare provider. Typically, tenofovir alafenamide is used in combination with other antiretroviral medications as part of a comprehensive HIV treatment regimen known as antiretroviral therapy (ART).
Common side effects of tenofovir alafenamide may include nausea, diarrhea, headache, fatigue, and changes in kidney function. It's important for individuals taking tenofovir alafenamide to adhere to their prescribed dosage regimen consistently and to report any unusual or severe symptoms to their healthcare provider promptly.
As with any medication, tenofovir alafenamide tablets can interact with other drugs, so it's important for patients to inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting tenofovir alafenamide therapy.
Overall, tenofovir alafenamide is an important component of HIV treatment and has been shown to be effective in helping people with HIV manage their condition and improve their quality of life.