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  • Active Ingredient: Acalabrutinib (100mg per capsule).
  • Manufacturer: Natco Pharma Ltd..
  • Mechanism of Action: Acalabrutinib works by blocking a specific abnormal protein (Bruton's tyrosine kinase) that signals cancer cells to grow and multiply. This action helps to slow down or stop the progression of the cancer.
  • Uses: It is used in adults for the treatment of specific hematologic malignancies (cancers of the white blood cells), including:
    • Mantle cell lymphoma (MCL), especially in patients who have received at least one prior treatment.
    • Chronic lymphocytic leukemia (CLL).
    • Small lymphocytic lymphoma (SLL).
  • Dosage and Administration: The typical recommended dose is one 100mg capsule taken orally twice daily, with or without food. The capsules should be swallowed whole; they should not be crushed, chewed, or opened.
  • Common Side Effects: Common side effects can include headache, diarrhea, fatigue, muscle and joint pain, anemia, and an increased risk of infections and bruising/bleeding.
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