Dolutegravir Emtricitabine and Tenofovir Alafenamide Tablets

Product Description

The combination of Dolutegravir (DTG), Emtricitabine (FTC), and Tenofovir Alafenamide (TAF) is a commonly used antiretroviral medication for the treatment of HIV-1 infection. This combination is often provided in a fixed-dose tablet to simplify the treatment regimen for individuals living with HIV.

Here are some key points about Dolutegravir, Emtricitabine, and Tenofovir Alafenamide tablets:

1. Dolutegravir (DTG):

   • DTG is an integrase strand transfer inhibitor (INSTI).
   • It inhibits the integrase enzyme, preventing the integration of viral DNA into the host cell genome, which is necessary for the replication of the HIV virus.

2. Emtricitabine (FTC):

   • FTC is a nucleoside reverse transcriptase inhibitor (NRTI).
   • It inhibits the reverse transcriptase enzyme, disrupting the replication of the HIV virus.

3. Tenofovir Alafenamide (TAF):

   • TAF is a prodrug of tenofovir, and it is a nucleotide reverse transcriptase inhibitor (NRTI).
   • TAF is an alternative to Tenofovir Disoproxil Fumarate (TDF), and it has a more favorable safety profile regarding potential effects on bone and kidney health.

Key points about the combination (Dolutegravir, Emtricitabine, and Tenofovir Alafenamide tablets):

• Indications: This combination is used for the treatment of HIV-1 infection in adults and pediatric patients.

• Dosage: The typical dosage involves taking one tablet orally once daily. The specific dosage may vary depending on the individual's health condition and the overall HIV treatment plan prescribed by a healthcare professional.

• Adherence: Consistent adherence to the prescribed regimen is crucial for the effectiveness of HIV treatment. Missing doses or not taking the medication as directed can lead to reduced efficacy and the development of drug resistance.

• Side Effects: Potential side effects may include nausea, headache, and fatigue. It's important to report any severe or persistent side effects to a healthcare provider.

• Pregnancy: The use of this combination during pregnancy should be discussed with a healthcare provider, taking into consideration the potential risks and benefits.

Individuals prescribed with this combination should follow the guidance of their healthcare provider, undergo regular monitoring, and communicate any concerns or side effects experienced during the treatment. As always, individual circumstances may vary, and healthcare providers can provide personalized information based on the patient's medical history and needs

Simplified Antiretroviral Therapy

This product merges three essential HIV-1 medications into a single daily tablet, making it easier for patients to maintain their antiretroviral regimen. The combination of Dolutegravir, Emtricitabine, and Tenofovir Alafenamide offers high efficacy with reduced pill burden, supporting improved adherence and better long-term outcomes for adults and adolescents.


Pharmaceutical Quality and Safety

Each film-coated tablet is designed for optimal stability, with unique markings and a blue to greenish-blue color for easy identification. The formula is odorless and free from fermentation smell. Manufactured and distributed according to international best practices, the product should be stored below 30C, protected from moisture and light, to maintain its 24-month shelf life.


Who Can Use This Fixed-Dose Combination?

The tablets are intended for adults and adolescents aged 12 years or older who weigh at least 35 kg and require HIV-1 treatment. Individuals must have a prescription from a registered healthcare provider. Due to the presence of certain excipients, patients with known hypersensitivity to any component should not use this medication.